ISCU

Across TCGA patient cohorts, ISCU mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISCU-associated genes across cancer lineages are A-Raf_pS299, Fibronectin, and Heregulin. Each is linked with ISCU in more than 1 cancer types. Because this analysis shows association rather than direction, both ISCU-to-partner and partner-to-ISCU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ISCU-low versus ISCU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCU→partner) and Y-score (partner→ISCU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.152	-3.000	.006	.036	3	1
UCEC	Fibronectin →	-0.352	-2.312	.022	.034	3	1
UCEC	Heregulin →	-0.150	-3.156	.009	.018	3	1
UCEC	HSP70 →	-0.408	-2.990	.029	.036	3	1
UCEC	INPP4B →	-0.308	-2.459	.041	.019	3	1
UCEC	JNK2 →	+0.299	+2.834	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

A-Raf_pS299 by ISCU expression — UCEC

Explore this box plot interactively →