ISCA2

Across TCGA patient cohorts, ISCA2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ISCA2-associated genes across cancer lineages are MIR1225, LINC02529, and MTCO2P30. Each is linked with ISCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISCA2-to-partner and partner-to-ISCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1225 grouped by ISCA2-low versus ISCA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA2→partner) and Y-score (partner→ISCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1225 →	+0.644	+5.027	<.001	.004	3	1
UCEC	LINC02529 →	+0.170	+4.256	.003	.008	3	1
UCEC	MTCO2P30 →	+0.279	+4.633	.001	.004	3	1
UCEC	RN7SKP132 →	+0.363	+5.877	<.001	.001	3	1
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1
UCEC	MIR5580 →	+0.775	+4.937	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MIR1225 by ISCA2 expression — UCEC

Explore this box plot interactively →