Across TCGA pan-cancer cohorts, ISCA1P1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ISCA1P1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ISCA1P1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ISCA1P1 expression acts as an unfavorable survival marker.

LIHC, LGG, and UCEC are the cancer types where ISCA1P1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.149	0.688	.015	9	view →
LGG	DFS	Median	All	0.077	0.845	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ISCA1P1 tumor-vs-normal RNA expression · all ISCA1P1 data types