Across TCGA pan-cancer cohorts, ISCA1P1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ISCA1P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ISCA1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ISCA1P1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where ISCA1P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ISCA1P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.234	.003	8	view →
LIHC	All	All	+0.152	<.001	5	view →
THCA	Male	All	−0.241	.003	2	view →
BRCA	All	III,IV	+0.226	.046	2	view →
KIRP	Male	All	−0.200	.029	1	view →
LUAD	All	All	+0.189	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: ISCA1P1 RNA expression & survival · all ISCA1P1 data types