ISCA1

Across TCGA pan-cancer cohorts, ISCA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ISCA1 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ISCA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ISCA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where ISCA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.527	0.799	.003	46	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	8	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.596	.012	8	view →
UCEC	OS	Quartile	All	0.778	0.968	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ISCA1–HNSC (DFS)

Open the HNSC breakdown →