ISCA1

Across TCGA patient cohorts, ISCA1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,450 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISCA1-associated genes across cancer lineages are HDHD3, AKR1C3, and MCRIP2. Each is linked with ISCA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ISCA1-to-partner and partner-to-ISCA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISCA1 versus HDHD3 in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA1→partner) and Y-score (partner→ISCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HDHD3 →	+0.802	+0.346	.006	<.001	3	5
LSCC	AKR1C3 →	+1.722	+0.375	<.001	<.001	3	5
HNSC	MCRIP2 →	+0.388	+0.234	.005	<.001	3	5
LSCC	ZDHHC11 →	+1.194	+0.395	<.001	<.001	3	5
HNSC	MCCC1 →	+0.798	+0.272	<.001	<.001	3	5
UCEC	PITRM1 →	+0.674	+0.309	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,450 associations by consensus.

ISCA1 vs HDHD3 — UCEC

Explore this scatter interactively →