ISCA1

Across TCGA cell cohorts, ISCA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,435 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ISCA1-associated GO terms across cancer lineages are Positive regulation of mRNA 3'-end processing, Immunoglobulin heavy chain V-D-J recombination, and Negative regulation of calcium ion transmembrane transporter activity. Each is linked with ISCA1 in more than 12 cancer types. Because this analysis shows association rather than direction, both ISCA1-to-partner and partner-to-ISCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA 3'-end processing grouped by ISCA1-low versus ISCA1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA1→partner) and Y-score (partner→ISCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of mRNA 3'-end processing →	+0.131	+0.966	<.001	<.001	3	13
BLOOD_Lymphoma	Immunoglobulin heavy chain V-D-J recombination →	+0.155	+0.684	<.001	.002	3	13
LIVER	Negative regulation of calcium ion transmembrane transporter activity →	+0.134	+0.716	<.001	<.001	3	12
LIVER	Proteasome regulatory particle assembly →	+0.171	+0.994	<.001	.001	3	11
SOFT_TISSUE	Positive regulation of chromosome condensation →	+0.177	+0.717	.002	<.001	3	10
CNS	Protein linear polyubiquitination →	-0.115	-0.545	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,435 associations by consensus.

Positive regulation of mRNA 3'-end processing by ISCA1 expression — PANCREAS

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