ISCA1

Across TCGA cell cohorts, ISCA1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISCA1-associated genes across cancer lineages are OR7A17 and OR6Q1. Each is linked with ISCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISCA1-to-partner and partner-to-ISCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7A17 grouped by ISCA1-low versus ISCA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA1→partner) and Y-score (partner→ISCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR7A17 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR7A17 by ISCA1 expression — LARGE_INTESTINE

Explore this box plot interactively →