IRX5

Across TCGA patient cohorts, IRX5 mutation is significantly associated with the RNA expression of many other genes, with 3,206 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRX5-associated genes across cancer lineages are RNA5SP73, RN7SL451P, and DEFB127. Each is linked with IRX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX5-to-partner and partner-to-IRX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP73 grouped by IRX5-low versus IRX5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX5→partner) and Y-score (partner→IRX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP73 →	+0.330	+5.837	<.001	.001	3	2
CESC	RN7SL451P →	+0.159	+4.455	<.001	.005	3	2
CESC	DEFB127 →	+0.062	+5.342	<.001	.002	3	2
UCEC	COX15 →	+0.405	+2.400	<.001	<.001	3	2
UCEC	AASDHPPT →	+0.393	+2.332	.004	.003	3	2
UCEC	EI24 →	+0.430	+2.415	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,206 associations by consensus.

RNA5SP73 by IRX5 expression — CESC

Explore this box plot interactively →