IRX5

Across TCGA pan-cancer cohorts, IRX5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IRX5 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IRX5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IRX5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRP show a favorable association.

LUAD, KIRP, and ACC are the cancer types where IRX5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.758	0.607	<.001	113	view →
KIRP	OS	Median	II,III,IV	0.925	0.706	<.001	82	view →
ACC	DFS	Quartile	All	0.110	0.763	<.001	77	view →
LGG	OS	Median	All	0.289	0.577	<.001	54	view →
BRCA	OS	Tertile	III,IV	0.966	0.855	<.001	35	view →
STAD	OS	Quartile	III,IV	0.664	0.306	.014	32	view →
HNSC	DFS	Median	III,IV	0.757	0.603	.002	32	view →
KIRC	OS	Median	All	0.759	0.859	.002	29	view →
THCA	OS	Tertile	III,IV	0.923	1.000	.009	29	view →
SKCM	OS	Quartile	II,III,IV	0.302	0.577	.001	29	view →
LIHC	OS	Tertile	All	0.590	0.798	.001	23	view →
SARC	DFS	Tertile	All	0.190	0.588	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IRX5–LUAD (OS)

Open the LUAD breakdown →