IRX5

Across TCGA patient cohorts, IRX5 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRX5-associated genes across cancer lineages are mTOR_pS2448, STAT3_pY705, and Tuberin. Each is linked with IRX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX5-to-partner and partner-to-IRX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by IRX5-low versus IRX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX5→partner) and Y-score (partner→IRX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.094	-1.395	.044	.043	3	2
UCEC	STAT3_pY705 →	-0.241	-1.352	.003	.034	3	2
UCEC	Tuberin →	+0.303	+1.836	<.001	.001	3	2
UCEC	ATM →	-0.437	-1.584	.002	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.689	+2.019	<.001	.001	3	2
UCEC	4E-BP1 →	+0.397	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

mTOR_pS2448 by IRX5 expression — UCEC

Explore this box plot interactively →