IRX4-AS1

Across TCGA pan-cancer cohorts, IRX4-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IRX4-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IRX4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IRX4-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and THYM show a favorable association.

UCEC, ACC, and KIRC are the cancer types where IRX4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.830	0.934	<.001	144	view →
ACC	DFS	Tertile	All	0.155	0.533	<.001	114	view →
KIRC	OS	Tertile	All	0.466	0.650	<.001	105	view →
PAAD	OS	Tertile	All	0.269	0.520	<.001	72	view →
STAD	DFS	Tertile	II,III,IV	0.210	0.427	.002	50	view →
BLCA	DFS	Tertile	All	0.412	0.571	<.001	39	view →
LAML	DFS	Tertile	All	0.861	0.335	.003	36	view →
LIHC	OS	Tertile	II,III,IV	0.051	0.696	<.001	36	view →
UVM	OS	Tertile	All	0.278	0.622	.029	33	view →
THYM	DFS	Tertile	All	0.975	0.804	.003	25	view →
KIRP	DFS	Tertile	All	0.761	0.924	.030	21	view →
BRCA	DFS	Tertile	II,III,IV	0.914	0.953	.003	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IRX4-AS1–UCEC (OS)

Open the UCEC breakdown →