IRX4-AS1

Across TCGA pan-cancer cohorts, IRX4-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IRX4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IRX4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IRX4-AS1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, LUSC, and PRAD are the cancer types where IRX4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IRX4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.739	.001	8	view →
LUSC	Female	All	+1.580	<.001	6	view →
PRAD	All	All	+0.786	<.001	2	view →
BRCA	Female	All	−0.278	.023	2	view →
KIRC	All	All	+0.096	.019	2	view →
LUAD	All	All	+0.206	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IRX4-AS1–HNSC

Open the HNSC breakdown →