IRS4

Across TCGA patient cohorts, IRS4 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,631 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IRS4-associated proteins across cancer lineages are SLC35E1, HMGB3, and TRIM2. Each is linked with IRS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRS4-to-partner and partner-to-IRS4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRS4 versus SLC35E1 in UCEC, with a Pearson correlation of -0.23.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS4→partner) and Y-score (partner→IRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC35E1 →	-0.694	-0.472	<.001	<.001	3	3
HNSC	HMGB3 →	+0.637	+0.554	<.001	.006	3	3
HNSC	TRIM2 →	+0.576	+0.394	<.001	.007	3	3
GBM	COPB2 →	-0.193	-0.268	<.001	.001	3	3
LSCC	OPA1 →	+0.418	+1.844	.001	.001	3	3
LSCC	BCL11A_S205 →	+0.563	+1.396	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,631 associations by consensus.

IRS4 vs SLC35E1 — UCEC

Explore this scatter interactively →