IRS4

Across TCGA pan-cancer cohorts, IRS4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IRS4 data layer compared with 10 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher IRS4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IRS4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UVM show a favorable association.

BRCA, UVM, and LUSC are the cancer types where IRS4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.939	0.874	<.001	80	view →
UVM	OS	Tertile	All	0.902	0.522	<.001	68	view →
LUSC	OS	Median	All	0.467	0.329	.001	54	view →
COAD	OS	Tertile	III,IV	0.217	0.806	<.001	54	view →
KIRC	DFS	Tertile	All	0.796	0.609	.004	33	view →
KIRP	DFS	Quartile	All	0.838	0.929	.010	27	view →
LIHC	OS	Tertile	All	0.359	0.721	<.001	21	view →
UCEC	DFS	Median	All	0.788	0.877	.002	18	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	18	view →
SKCM	OS	Quartile	IV	0.147	0.873	.011	15	view →
STAD	DFS	Quartile	All	0.521	0.756	.011	14	view →
PRAD	DFS	Median	All	0.960	0.907	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IRS4–BRCA (DFS)

Open the BRCA breakdown →