IRS4

Across TCGA patient cohorts, IRS4 protein abundance is significantly associated with the RNA expression of many other genes, with 11,877 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRS4-associated genes across cancer lineages are VSIG1, ATG4A, and ZNF423. Each is linked with IRS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRS4-to-partner and partner-to-IRS4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRS4 versus VSIG1 in LSCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS4→partner) and Y-score (partner→IRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VSIG1 →	+1.022	+1.102	.004	.002	3	1
LSCC	ATG4A →	+1.503	+2.120	<.001	<.001	3	1
LSCC	ZNF423 →	-0.711	-1.248	<.001	.001	3	1
LSCC	APLP1 →	-0.907	-1.231	.002	.006	3	1
LSCC	FSD1L →	-0.656	-1.360	.006	.003	3	1
LSCC	RERGL →	+0.526	+1.271	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,877 associations by consensus.

IRS4 vs VSIG1 — LSCC

Explore this scatter interactively →