IRS4

Across TCGA patient cohorts, IRS4 mutation is significantly associated with the RNA expression of many other genes, with 5,597 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRS4-associated genes across cancer lineages are LSM2, GOT1, and CDC20. Each is linked with IRS4 in more than 4 cancer types. Because this analysis shows association rather than direction, both IRS4-to-partner and partner-to-IRS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSM2 grouped by IRS4-low versus IRS4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS4→partner) and Y-score (partner→IRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LSM2 →	+0.384	+2.000	.002	.009	3	5
COAD	GOT1 →	+0.549	+2.335	<.001	.002	3	4
LUAD	CDC20 →	+0.955	+3.602	.001	.001	3	4
LUAD	HROB →	+0.778	+2.099	<.001	.003	3	4
LUAD	AUNIP →	+0.615	+3.357	.002	.004	3	4
UCEC	HAUS8 →	+0.432	+1.758	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,597 associations by consensus.

LSM2 by IRS4 expression — COAD

Explore this box plot interactively →