IRS4

Across TCGA patient cohorts, IRS4 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRS4-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and ERK2. Each is linked with IRS4 in more than 3 cancer types. Because this analysis shows association rather than direction, both IRS4-to-partner and partner-to-IRS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by IRS4-low versus IRS4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS4→partner) and Y-score (partner→IRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.903	+1.708	.002	.026	3	4
STAD	eEF2 →	+0.495	+3.584	<.001	.002	3	3
STAD	ERK2 →	+0.332	+3.584	.013	.002	3	3
COAD	GAPDH →	+0.570	+3.169	.003	.017	3	3
STAD	Rictor_pT1135 →	-0.183	-3.000	.005	.033	3	3
STAD	TFRC →	+0.722	+2.459	.007	.019	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Caspase-7-cleavedD198 by IRS4 expression — COAD

Explore this box plot interactively →