IRS4

Across TCGA cell cohorts, IRS4 mutation is significantly associated with the RNA expression of many other genes, with 1,096 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRS4-associated genes across cancer lineages are KRT73, OR8B4, and PRLHR. Each is linked with IRS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRS4-to-partner and partner-to-IRS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT73 grouped by IRS4-low versus IRS4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS4→partner) and Y-score (partner→IRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRT73 →	+0.057	+3.215	<.001	.007	3	2
OVARY	OR8B4 →	+0.010	+3.807	<.001	.009	3	2
BLOOD_Lymphoma	PRLHR →	+0.013	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	IFNL3 →	+0.142	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.207	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,096 associations by consensus.

KRT73 by IRS4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →