Across TCGA patient cohorts, IRS2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,933 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRS2-associated genes across cancer lineages are ADPRHL1, NAXD, and PMP22. Each is linked with IRS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both IRS2-to-partner and partner-to-IRS2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS2→partner) and Y-score (partner→IRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ADPRHL1 →	+0.659	+0.441	<.001	.007	3	5
LUAD	NAXD →	+0.531	+0.768	<.001	<.001	3	5
UCEC	PMP22 →	+0.808	+0.530	.001	.001	3	4
LSCC	MELTF →	+1.152	+0.522	<.001	<.001	3	4
BRCA	GNG4 →	+1.056	+0.396	<.001	<.001	3	4
LUAD	LINC01132 →	-0.634	-0.620	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,933 associations by consensus.

Exploration

IRS2 survival (RNA) · tumor vs normal (RNA) · all IRS2 data types