Across TCGA patient cohorts, IRS2 mutation is significantly associated with the RNA expression of many other genes, with 3,245 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRS2-associated genes across cancer lineages are RNU1-35P, LINC00609, and DUX4L17. Each is linked with IRS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRS2-to-partner and partner-to-IRS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS2→partner) and Y-score (partner→IRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-35P →	+1.059	+5.436	<.001	.005	3	3
BLCA	LINC00609 →	+0.099	+3.971	.007	.005	3	2
BLCA	DUX4L17 →	+0.031	+5.229	<.001	.002	3	2
BLCA	LLPHP1 →	+0.119	+4.433	<.001	.007	3	2
CESC	TSPAN9-IT1 →	+0.096	+3.653	<.001	.009	3	2
SKCM	RNA5SP330 →	+0.433	+5.159	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,245 associations by consensus.

Exploration

IRS2 survival (RNA) · tumor vs normal (RNA) · all IRS2 data types