IRS1

Across TCGA cell cohorts, IRS1 mutation is significantly associated with the RNA expression of many other genes, with 1,299 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRS1-associated genes across cancer lineages are OR6C75, LMNTD1, and AGXT2. Each is linked with IRS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRS1-to-partner and partner-to-IRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C75 grouped by IRS1-low versus IRS1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS1→partner) and Y-score (partner→IRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR6C75 →	+0.015	+4.266	<.001	.004	3	3
BLOOD_Myeloma	LMNTD1 →	+0.095	+3.906	<.001	.009	3	2
PANCREAS	AGXT2 →	+0.049	+4.139	<.001	.001	3	2
PANCREAS	OTC →	+1.078	+3.491	.001	.008	3	2
LUNG_SCLC	SIGLEC8 →	+0.004	+3.232	<.001	.008	3	2
LARGE_INTESTINE	PRDM4 →	+0.403	+2.584	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,299 associations by consensus.

OR6C75 by IRS1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →