IRGM

Across TCGA patient cohorts, IRGM RNA expression is significantly associated with the go_rna of many other GO terms, with 7,077 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IRGM-associated GO terms across cancer lineages are Chondrocyte differentiation, Regulation of cilium assembly, and Regulation of myeloid cell differentiation. Each is linked with IRGM in more than 21 cancer types. Because this analysis shows association rather than direction, both IRGM-to-partner and partner-to-IRGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chondrocyte differentiation grouped by IRGM-low versus IRGM-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGM→partner) and Y-score (partner→IRGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Chondrocyte differentiation →	+0.054	+0.149	<.001	<.001	3	22
STAD	Regulation of cilium assembly →	+0.050	+0.149	<.001	<.001	3	21
STAD	Regulation of myeloid cell differentiation →	+0.063	+0.154	<.001	<.001	3	21
STAD	Positive regulation of binding →	+0.055	+0.145	<.001	<.001	3	21
STAD	Response to ionizing radiation →	+0.063	+0.159	<.001	<.001	3	20
STAD	Regulation of protein localization to nucleus →	+0.078	+0.152	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,077 associations by consensus.

Chondrocyte differentiation by IRGM expression — STAD

Explore this box plot interactively →