IRGM

Across TCGA pan-cancer cohorts, IRGM RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IRGM data layer compared with 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IRGM RNA is associated with better overall survival. In most high-consensus cancer types, elevated IRGM expression acts as an unfavorable survival marker, although some lineages such as LUAD and SCLC show a favorable association.

LUAD, SCLC, and KIRC are the cancer types where IRGM RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.378	0.119	<.001	105	view →
SCLC	DFS	Tertile	III,IV	0.851	0.219	<.001	74	view →
KIRC	DFS	Median	All	0.548	0.700	<.001	60	view →
LGG	OS	Median	All	0.757	0.860	<.001	41	view →
SKCM	OS	Tertile	IV	0.748	0.148	.002	31	view →
THCA	DFS	Tertile	II,III,IV	0.790	0.964	.002	31	view →
UCEC	OS	Median	III,IV	0.704	0.455	.006	28	view →
ESCA	OS	Median	III,IV	0.739	0.462	.010	27	view →
READ	DFS	Tertile	All	0.335	0.711	.008	21	view →
CESC	DFS	Tertile	All	0.819	0.626	.001	16	view →
SARC	OS	Tertile	All	0.595	0.805	.007	14	view →
UVM	DFS	Tertile	III,IV	0.107	0.677	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IRGM–LUAD (OS)

Open the LUAD breakdown →