IRGM

Across TCGA cell cohorts, IRGM RNA expression is significantly associated with the go_rna of many other GO terms, with 1,838 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IRGM-associated GO terms across cancer lineages are CAMKK-AMPK signaling cascade, Positive regulation of cytoskeleton organization, and Positive regulation of supramolecular fiber organization. Each is linked with IRGM in more than 6 cancer types. Because this analysis shows association rather than direction, both IRGM-to-partner and partner-to-IRGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAMKK-AMPK signaling cascade grouped by IRGM-low versus IRGM-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGM→partner) and Y-score (partner→IRGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CAMKK-AMPK signaling cascade →	-0.135	-1.019	<.001	<.001	3	7
SOFT_TISSUE	Positive regulation of cytoskeleton organization →	+0.062	+0.231	<.001	.003	3	6
SOFT_TISSUE	Positive regulation of supramolecular fiber organization →	+0.079	+0.349	<.001	.009	3	6
BLOOD_Lymphoma	Regulation of ubiquitin-dependent protein catabolic process →	+0.038	+0.479	.002	.004	3	6
BLOOD_Lymphoma	MHC class I protein complex assembly →	+0.091	+0.321	<.001	.002	3	6
BLOOD_Lymphoma	Peptide antigen assembly with MHC class I protein complex →	+0.091	+0.321	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,838 associations by consensus.

CAMKK-AMPK signaling cascade by IRGM expression — BLOOD_Leukemia

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