IRF8

Across TCGA cell cohorts, IRF8 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRF8-associated genes across cancer lineages are OPRPN, CA5A, and C9orf92. Each is linked with IRF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF8-to-partner and partner-to-IRF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by IRF8-low versus IRF8-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF8→partner) and Y-score (partner→IRF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
BLOOD_Leukemia	TRIM48 →	+0.118	+4.269	.002	.002	3	1
BLOOD_Leukemia	ZIC3 →	+0.015	+4.060	<.001	.003	3	1
BLOOD_Leukemia	OR10G6 →	+0.018	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OPRPN by IRF8 expression — URINARY_TRACT

Explore this box plot interactively →