IRF2BP2

Across TCGA patient cohorts, IRF2BP2 mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF2BP2-associated genes across cancer lineages are RNA5SP140, RNU6-1296P, and HSBP1P1. Each is linked with IRF2BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF2BP2-to-partner and partner-to-IRF2BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP140 grouped by IRF2BP2-low versus IRF2BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BP2→partner) and Y-score (partner→IRF2BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP140 →	+1.168	+3.200	<.001	.006	3	2
UCEC	RNU6-1296P →	+0.161	+4.010	<.001	.007	3	2
UCEC	HSBP1P1 →	+0.475	+2.909	<.001	<.001	3	2
DLBC	DIAPH3-AS1 →	+0.101	+4.655	.003	.002	3	1
DLBC	BCAS2P1 →	+0.390	+4.099	<.001	.008	3	1
SKCM	TUBB8P3 →	+0.074	+5.097	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

RNA5SP140 by IRF2BP2 expression — UCEC

Explore this box plot interactively →