IRF2-DT

Across TCGA pan-cancer cohorts, IRF2-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IRF2-DT data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IRF2-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IRF2-DT expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

SKCM, BRCA, and LGG are the cancer types where IRF2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.670	0.563	<.001	111	view →
BRCA	OS	Tertile	All	0.980	0.939	.001	61	view →
LGG	DFS	Median	All	0.646	0.821	<.001	52	view →
STAD	OS	Tertile	All	0.703	0.190	.004	52	view →
ACC	OS	Median	II,III,IV	0.676	1.000	.001	49	view →
READ	DFS	Median	II,III,IV	0.910	0.483	<.001	37	view →
MESO	OS	Tertile	All	0.643	0.467	.007	28	view →
GBM	DFS	Quartile	All	0.179	0.340	.008	27	view →
PAAD	OS	Quartile	All	0.410	0.140	.006	24	view →
LUSC	DFS	Median	III,IV	0.635	0.351	.003	24	view →
ESCA	DFS	Median	II,III,IV	1.000	0.303	.004	21	view →
LUAD	OS	Quartile	All	0.649	0.283	.007	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IRF2-DT–SKCM (DFS)

Open the SKCM breakdown →