IRF2-DT

Across TCGA pan-cancer cohorts, IRF2-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IRF2-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IRF2-DT RNA is repressed in tumor relative to normal tissue. In most cancer types IRF2-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUAD are the cancer types where IRF2-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IRF2-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.649	<.001	10	view →
THCA	Male	All	−0.600	<.001	7	view →
LUAD	Male	III,IV	−0.731	<.001	6	view →
KIRC	Male	II,III,IV	−0.588	<.001	6	view →
BRCA	Female	All	−0.495	<.001	6	view →
STAD	All	II,III,IV	+0.438	.009	5	view →
LIHC	Male	All	+0.451	.005	3	view →
BLCA	Male	III,IV	−0.759	.022	2	view →
UCEC	All	All	−0.483	.002	2	view →
COAD	All	IV	−0.481	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IRF2-DT–KICH

Open the KICH breakdown →