Across TCGA patient cohorts, IRAK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,691 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IRAK4-associated proteins across cancer lineages are TWF1, CACNA2D1, and FGD3. Each is linked with IRAK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both IRAK4-to-partner and partner-to-IRAK4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK4→partner) and Y-score (partner→IRAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TWF1 →	+0.268	+0.440	<.001	<.001	3	5
LSCC	CACNA2D1 →	+0.562	+0.409	<.001	<.001	3	4
BRCA	FGD3 →	+0.582	+0.376	<.001	<.001	3	4
GBM	SSRP1 →	-0.357	-0.259	.005	.001	3	4
BRCA	ATAD3B →	-0.561	-0.376	<.001	<.001	3	4
GBM	BLOC1S5 →	+0.319	+0.239	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,691 associations by consensus.

Exploration

IRAK4 survival (RNA) · tumor vs normal (RNA) · all IRAK4 data types