Across TCGA cell cohorts, IRAK4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRAK4-associated genes across cancer lineages are CCDC172, OR14K1, and CENPVL3. Each is linked with IRAK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK4-to-partner and partner-to-IRAK4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK4→partner) and Y-score (partner→IRAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCDC172 →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR14K1 →	+0.081	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CENPVL3 →	+0.346	+3.920	<.001	.005	3	1
BLOOD_Leukemia	LYZL2 →	+0.033	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	C14orf177 →	+0.052	+4.922	.001	.009	3	1
BLOOD_Leukemia	OR6C70 →	+0.021	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

IRAK4 survival (RNA) · tumor vs normal (RNA) · all IRAK4 data types