IRAK3

Across TCGA patient cohorts, IRAK3 mutation is significantly associated with the RNA expression of many other genes, with 4,282 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK3-associated genes across cancer lineages are RPL12P5, RNU1-73P, and ZFP91-CNTF. Each is linked with IRAK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRAK3-to-partner and partner-to-IRAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P5 grouped by IRAK3-low versus IRAK3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK3→partner) and Y-score (partner→IRAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL12P5 →	+0.040	+3.282	<.001	.005	3	3
LIHC	RNU1-73P →	+0.314	+4.179	<.001	.004	3	3
UCEC	ZFP91-CNTF →	+0.018	+1.628	.004	.005	3	3
SKCM	MIR191 →	+0.153	+2.817	.001	.005	3	3
SKCM	RNU6-1154P →	+0.222	+2.551	.001	.003	3	3
GBM	OR6M3P →	+0.091	+5.352	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,282 associations by consensus.

RPL12P5 by IRAK3 expression — SKCM

Explore this box plot interactively →