IRAK2

Across TCGA cell cohorts, IRAK2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IRAK2-associated genes across cancer lineages are GAGE12J, BOD1L2, and EPPIN. Each is linked with IRAK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK2-to-partner and partner-to-IRAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12J grouped by IRAK2-low versus IRAK2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK2→partner) and Y-score (partner→IRAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
SOFT_TISSUE	BOD1L2 →	+0.006	+5.977	<.001	.001	3	1
BLOOD_Lymphoma	EPPIN →	+0.053	+4.714	<.001	.002	3	1
SKIN	ACTRT1 →	+0.003	+4.022	<.001	.006	3	1
SKIN	MAJIN →	+0.069	+3.658	.001	.005	3	1
SKIN	P2RY13 →	+0.006	+4.099	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

GAGE12J by IRAK2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →