IRAG2

Across TCGA patient cohorts, IRAG2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,891 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IRAG2-associated genes across cancer lineages are CENPUP2, RHOH, and GLRX. Each is linked with IRAG2 in more than 6 cancer types. Because this analysis shows association rather than direction, both IRAG2-to-partner and partner-to-IRAG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRAG2 versus CENPUP2 in LSCC, with a Pearson correlation of 0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAG2→partner) and Y-score (partner→IRAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CENPUP2 →	+1.188	+0.980	<.001	<.001	3	7
LSCC	RHOH →	+0.861	+0.689	<.001	<.001	3	6
COAD	GLRX →	+0.909	+0.541	.006	.007	3	5
GBM	VNN2 →	+0.969	+0.542	<.001	<.001	3	5
GBM	FLI1 →	+0.643	+0.520	<.001	<.001	3	5
GBM	CLEC4E →	+1.029	+0.468	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,891 associations by consensus.

IRAG2 vs CENPUP2 — LSCC

Explore this scatter interactively →