Q-omics provides the consensus-scored CENPUP2 profile across patient tissues and cancer cell-line models. CENPUP2 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, CENPUP2 is differentially expressed in 4, with the highest sampling consensus in COAD. Additionally, CENPUP2 RNA expression shows 13,956 significant gene co-expression associations, with the highest sampling consensus in DLBC. Together, these results highlight SKCM, COAD, and DLBC as cancer lineages where CENPUP2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CENPUP2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CENPUP2 survival associations across molecular data types. CENPUP2 RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CENPUP2 RNA expression–survival associations across cancer types. High CENPUP2 expression shows unfavorable associations in LGG, but favorable associations in SKCM, LUAD, CHOL, OV and UCS. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify SKCM as the clearest survival context for CENPUP2 RNA expression.
This table summarizes CENPUP2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for CENPUP2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CENPUP2 shows lower tumor expression in COAD and THCA and higher tumor expression in KIRC and STAD. The COAD box plot shows higher CENPUP2 RNA expression in normal versus tumor tissue (log2 FC = −0.088, t-test p < 0.001).
This table shows molecular features associated with CENPUP2 in patient tissues and cancer cell lines. In patient samples, CENPUP2 shows the broadest associations at the RNA and protein expression levels, with DLBC recurring as the lineage with the largest associated feature set.
