CENPUP2

Across TCGA pan-cancer cohorts, CENPUP2 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated CENPUP2 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CENPUP2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CENPUP2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CHOL show a favorable association.

SKCM, LGG, and CHOL are the cancer types where CENPUP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	All	0.698	0.591	.002	54	view →
LGG	DFS	Median	All	0.652	0.807	<.001	50	view →
CHOL	DFS	Tertile	II,III,IV	1.000	0.133	.010	36	view →
LUAD	DFS	Quartile	All	0.861	0.747	.004	36	view →
OV	OS	Quartile	IV	0.661	0.306	.004	26	view →
UCS	DFS	Tertile	All	0.639	0.194	.016	18	view →
BRCA	OS	Tertile	IV	0.989	0.574	.023	18	view →
ACC	DFS	Tertile	III,IV	0.265	0.691	.026	9	view →
LIHC	OS	Tertile	All	0.937	0.757	.017	9	view →
ESCA	DFS	Quartile	III,IV	0.530	0.231	.032	7	view →
KIRP	OS	Quartile	All	0.460	0.765	.013	6	view →
THCA	OS	Quartile	IV	0.573	0.873	.037	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

CENPUP2–SKCM (DFS)

Open the SKCM breakdown →