IRAG1-AS1

Across TCGA pan-cancer cohorts, IRAG1-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IRAG1-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher IRAG1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IRAG1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and MESO show a favorable association.

KICH, LIHC, and UVM are the cancer types where IRAG1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	II,III,IV	0.540	0.958	<.001	105	view →
LIHC	OS	Quartile	III,IV	0.290	0.682	<.001	32	view →
UVM	DFS	Quartile	II,III,IV	0.951	0.592	.017	27	view →
COAD	OS	Median	II,III,IV	0.479	0.713	.009	23	view →
MESO	DFS	Tertile	III,IV	0.521	0.297	.014	20	view →
ESCA	OS	Median	III,IV	0.677	0.435	.013	15	view →
ACC	DFS	Tertile	II,III,IV	0.376	0.688	.005	12	view →
KIRC	DFS	Median	IV	0.231	0.407	.022	12	view →
PAAD	DFS	Tertile	All	0.632	0.383	.014	11	view →
BRCA	DFS	Quartile	IV	0.741	0.220	.019	10	view →
CESC	OS	Quartile	IV	0.605	0.083	.012	6	view →
LUSC	DFS	Median	IV	0.827	0.134	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IRAG1-AS1–KICH (DFS)

Open the KICH breakdown →