IRAG1-AS1

Across TCGA pan-cancer cohorts, IRAG1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IRAG1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where IRAG1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types IRAG1-AS1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and KICH are the cancer types where IRAG1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IRAG1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−0.307	<.001	6	view →
KIRC	Male	II,III,IV	−0.185	<.001	5	view →
KICH	All	All	−0.232	.012	4	view →
BRCA	Female	All	+0.121	.012	4	view →
LIHC	All	All	+0.079	.001	4	view →
STAD	All	All	−0.262	.007	3	view →
HNSC	All	II,III,IV	−0.245	.008	3	view →
LUSC	All	III,IV	−0.426	.009	2	view →
PRAD	All	All	+0.399	<.001	2	view →
CHOL	All	All	+0.165	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IRAG1-AS1–KIRP

Open the KIRP breakdown →