IQUB

Across TCGA cell cohorts, IQUB mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQUB-associated genes across cancer lineages are KIR3DL1, KRTAP4-7, and USP17L11. Each is linked with IQUB in more than 1 cancer types. Because this analysis shows association rather than direction, both IQUB-to-partner and partner-to-IQUB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR3DL1 grouped by IQUB-low versus IQUB-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQUB→partner) and Y-score (partner→IQUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KIR3DL1 →	+0.013	+5.029	<.001	.006	3	2
LUNG_NSCLC_LUAD	KRTAP4-7 →	+0.169	+4.212	.004	.007	3	2
KIDNEY	USP17L11 →	+0.026	+5.000	<.001	.005	3	1
KIDNEY	USP17L20 →	+0.026	+5.000	<.001	.005	3	1
KIDNEY	USP17L18 →	+0.026	+5.000	<.001	.005	3	1
URINARY_TRACT	SMYD1 →	+0.015	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

KIR3DL1 by IQUB expression — LUNG_SCLC

Explore this box plot interactively →