IQSEC2

Across TCGA patient cohorts, IQSEC2 RNA expression is significantly associated with the RNA expression of many other genes, with 18,524 significant associations in total. KIRP shows the largest number of these associations.

The most reproducible IQSEC2-associated genes across cancer lineages are KDM5C, USP27X-AS1, and ZBTB4. Each is linked with IQSEC2 in more than 29 cancer types. Because this analysis shows association rather than direction, both IQSEC2-to-partner and partner-to-IQSEC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQSEC2 versus KDM5C in ACC, with a Pearson correlation of 0.47.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC2→partner) and Y-score (partner→IQSEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	KDM5C →	+0.912	+1.103	<.001	<.001	3	30
ACC	USP27X-AS1 →	+0.990	+0.947	<.001	<.001	3	30
KICH	ZBTB4 →	+0.857	+0.500	<.001	<.001	3	30
ACC	TSR2 →	+1.064	+1.083	<.001	<.001	3	30
KIRP	MECP2 →	+0.782	+0.593	<.001	<.001	3	30
ACC	GRIPAP1 →	+0.856	+0.812	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,524 associations by consensus.

IQSEC2 vs KDM5C — ACC

Explore this scatter interactively →