IQSEC1

Across TCGA patient cohorts, IQSEC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,334 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IQSEC1-associated proteins across cancer lineages are PRELP, APPL1, and OLFML3. Each is linked with IQSEC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both IQSEC1-to-partner and partner-to-IQSEC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQSEC1 versus PRELP in CCRCC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC1→partner) and Y-score (partner→IQSEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PRELP →	+0.843	+0.393	<.001	.001	3	6
BRCA	APPL1 →	+0.259	+0.554	<.001	.002	3	5
OV	OLFML3 →	+0.763	+0.960	.002	.001	3	5
OV	VIM_S72 →	+1.369	+0.790	.003	.005	3	5
BRCA	RABEP1 →	+0.362	+0.375	.001	.001	3	5
BRCA	RBSN →	+0.219	+0.458	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,334 associations by consensus.

IQSEC1 vs PRELP — CCRCC

Explore this scatter interactively →