Across TCGA patient cohorts, IQGAP3 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQGAP3-associated genes across cancer lineages are Rad50, eEF2, and STAT3_pY705. Each is linked with IQGAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IQGAP3-to-partner and partner-to-IQGAP3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP3→partner) and Y-score (partner→IQGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Rad50 →	-0.138	-3.575	.020	.002	3	3
UCEC	eEF2 →	+0.277	+2.321	.007	.005	3	3
UCEC	STAT3_pY705 →	-0.303	-2.192	<.001	<.001	3	3
UCEC	TFRC →	+0.450	+1.906	.003	.014	3	3
UCEC	ATM →	-0.445	-2.649	<.001	<.001	3	3
SKCM	PKC-a →	-0.461	-3.169	.008	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Exploration

IQGAP3 survival (RNA) · tumor vs normal (RNA) · all IQGAP3 data types