Across TCGA cell cohorts, IQGAP3 mutation is significantly associated with the RNA expression of many other genes, with 278 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQGAP3-associated genes across cancer lineages are AGRP, SLURP2, and HINT3. Each is linked with IQGAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQGAP3-to-partner and partner-to-IQGAP3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP3→partner) and Y-score (partner→IQGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AGRP →	+0.050	+3.807	<.001	.003	3	2
LUNG_SCLC	SLURP2 →	+0.426	+5.029	<.001	.006	3	2
LARGE_INTESTINE	HINT3 →	+0.547	+2.743	.008	.001	3	2
LARGE_INTESTINE	RPF1 →	+0.639	+3.087	<.001	.006	3	2
LARGE_INTESTINE	YARS1 →	+0.599	+2.743	.007	.001	3	2
LARGE_INTESTINE	TOM1L1 →	+0.567	+3.321	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 278 associations by consensus.

Exploration

IQGAP3 survival (RNA) · tumor vs normal (RNA) · all IQGAP3 data types