IQCM

Across TCGA patient cohorts, IQCM RNA expression is significantly associated with the protein abundance of many other proteins, with 8,338 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IQCM-associated proteins across cancer lineages are ZZEF1, CHERP, and CPSF6. Each is linked with IQCM in more than 2 cancer types. Because this analysis shows association rather than direction, both IQCM-to-partner and partner-to-IQCM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQCM versus ZZEF1 in HNSC, with a Pearson correlation of -0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCM→partner) and Y-score (partner→IQCM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZZEF1 →	-0.178	-1.184	<.001	<.001	3	3
OV	CHERP →	+0.180	+0.173	.006	.003	3	3
LSCC	CPSF6 →	+0.212	+0.818	<.001	<.001	3	3
LSCC	TET2_S99 →	+0.486	+0.652	.002	<.001	3	3
HNSC	PTPRF →	+0.474	+0.727	<.001	<.001	3	3
LSCC	PUM2 →	+0.262	+0.691	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,338 associations by consensus.

IQCM vs ZZEF1 — HNSC

Explore this scatter interactively →