IQCM

Across TCGA pan-cancer cohorts, IQCM RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IQCM’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IQCM RNA is repressed in tumor relative to normal tissue. In most cancer types IQCM is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, HNSC, and LUSC are the cancer types where IQCM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IQCM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.704	<.001	12	view →
HNSC	Male	All	+0.303	<.001	12	view →
LUSC	All	II,III,IV	+0.303	<.001	6	view →
READ	All	All	−0.449	<.001	3	view →
BLCA	All	All	+0.233	.035	3	view →
LUAD	All	All	+0.103	.003	3	view →
BRCA	All	III,IV	−0.016	.036	2	view →
LIHC	All	All	+0.022	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IQCM–COAD

Open the COAD breakdown →