IQCM

Across TCGA cell cohorts, IQCM RNA expression is significantly associated with the go_rna of many other GO terms, with 330 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible IQCM-associated GO terms across cancer lineages are Negative regulation of ubiquitin-dependent protein catabolic process, Regulation of miRNA transcription, and Negative regulation of protein catabolic process. Each is linked with IQCM in more than 5 cancer types. Because this analysis shows association rather than direction, both IQCM-to-partner and partner-to-IQCM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ubiquitin-dependent protein catabolic process grouped by IQCM-low versus IQCM-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCM→partner) and Y-score (partner→IQCM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.089	+0.463	.005	.003	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of miRNA transcription →	+0.060	+0.160	.001	.009	3	4
OESOPHAGUS	Negative regulation of protein catabolic process →	+0.089	+0.493	<.001	<.001	2	4
OESOPHAGUS	Ribosome disassembly →	+0.075	+0.342	.005	.008	3	3
BONE	Negative regulation of stress granule assembly →	+0.129	+0.019	.002	.007	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of ferroptosis →	+0.067	+0.225	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 330 associations by consensus.

Negative regulation of ubiquitin-dependent protein catabolic process by IQCM expression — OESOPHAGUS

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