IQCK

Across TCGA patient cohorts, IQCK mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCK-associated genes across cancer lineages are eIF4E, Acetyl-a-Tubulin-Lys40, and INPP4B. Each is linked with IQCK in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCK-to-partner and partner-to-IQCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IQCK-low versus IQCK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCK→partner) and Y-score (partner→IQCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.209	+2.584	.033	.011	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.630	+2.584	.007	.011	3	1
UCEC	INPP4B →	-0.378	-3.321	.012	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.156	-3.000	.047	.036	3	1
UCEC	JNK2 →	+0.224	+3.700	.015	.001	3	1
UCEC	Ku80 →	+0.263	+1.887	.016	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by IQCK expression — UCEC

Explore this box plot interactively →