IQCK

Across TCGA pan-cancer cohorts, IQCK RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IQCK data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IQCK RNA is associated with better overall survival. In most high-consensus cancer types, elevated IQCK expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, READ, and BLCA are the cancer types where IQCK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.713	0.534	<.001	116	view →
READ	OS	Tertile	All	0.915	0.442	<.001	75	view →
BLCA	OS	Median	All	0.438	0.731	<.001	60	view →
BRCA	OS	Tertile	IV	0.820	0.159	<.001	31	view →
STAD	OS	Tertile	All	0.592	0.854	.002	30	view →
UCEC	OS	Tertile	III,IV	0.738	0.435	.004	28	view →
LGG	OS	Tertile	All	0.442	0.615	<.001	23	view →
ACC	DFS	Median	III,IV	0.583	0.111	.001	20	view →
LUSC	DFS	Quartile	All	0.322	0.508	.002	19	view →
SKCM	DFS	Tertile	II,III,IV	0.731	0.603	.012	15	view →
KIRP	DFS	Quartile	All	0.931	0.614	.029	14	view →
HNSC	DFS	Median	III,IV	0.423	0.240	.011	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IQCK–KIRC (OS)

Open the KIRC breakdown →