Across TCGA patient cohorts, IQCJ mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCJ-associated genes across cancer lineages are mTOR_pS2448, Notch1, and Rab25. Each is linked with IQCJ in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCJ-to-partner and partner-to-IQCJ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCJ→partner) and Y-score (partner→IQCJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.188	-2.980	.021	.036	3	1
UCEC	Notch1 →	+0.273	+2.817	<.001	.036	3	1
UCEC	Rab25 →	-0.371	-3.169	.041	.020	3	1
UCEC	Annexin-1 →	+1.073	+3.019	<.001	.019	3	1
UCEC	TFRC →	+0.745	+3.169	.010	.020	3	1
UCEC	ATM →	-0.665	-3.169	.007	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

IQCJ survival (RNA) · tumor vs normal (RNA) · all IQCJ data types