IQCH

Across TCGA patient cohorts, IQCH mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCH-associated genes across cancer lineages are eEF2, IGFBP2, and 14-3-3_beta. Each is linked with IQCH in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCH-to-partner and partner-to-IQCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by IQCH-low versus IQCH-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCH→partner) and Y-score (partner→IQCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	eEF2 →	+0.310	+2.824	.023	.036	3	2
UCEC	IGFBP2 →	-0.484	-1.137	.005	.037	3	2
UCEC	14-3-3_beta →	-0.080	-1.973	.003	.002	3	2
UCEC	FoxM1 →	+0.202	+1.999	.003	<.001	3	2
UCEC	MEK1 →	+0.372	+1.807	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.112	-2.057	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

eEF2 by IQCH expression — BLCA

Explore this box plot interactively →